5 Traditional Menopause Treatment Options (and the Pro's and Con's of Each)

5 Minutes
Traditional Menopause Treatment Options
Jody Allen
If you are suffering from the symptoms of menopause, you may be researching the traditional menopause treatment options.

There are several traditional treatment options available to manage menopause symptoms. These options can be divided into two main categories: hormone therapy and non-hormonal treatments. It's important to note that the suitability of these treatments can vary for each individual, and the decision to pursue any specific treatment should be made in consultation with a healthcare professional.

Traditional Menopause Treatment Options

Here are some traditional treatment options for menopause:

1. Hormone Replacement Therapy

Hormone therapy involves taking medications that contain hormones, typically estrogen alone or a combination of estrogen and progesterone (for women with an intact uterus). Hormone therapy can help alleviate a wide range of menopause symptoms, including hot flashes, night sweats, vaginal dryness, and mood changes. It can also provide long-term benefits such as reduced risk of osteoporosis and certain types of cancer.

Hormone therapy is available in various forms, including pills, patches, gels, creams, and vaginal rings. Hormone replacement therapy (HRT) is considered one of the most effective treatments for menopause symptoms.

By effectively managing menopause symptoms, HRT can significantly improve a woman's quality of life, allowing her to better cope with the physical and emotional changes associated with menopause.

More Reading: The Ultimate Guide to Hormone Replacement Therapy

Traditional Menopause Treatment Options

Pro's of Using Hormone Replacement Therapy:

Hormone replacement therapy (HRT) has several potential benefits for women experiencing menopause symptoms. Here are some of the pros associated with HRT:

Relief from Menopause Symptoms:

HRT is highly effective in relieving common menopause symptoms such as hot flashes, night sweats, vaginal dryness, and mood changes. By providing supplemental hormones (estrogen and/or progesterone), HRT can help restore hormonal balance and alleviate these symptoms, leading to improved quality of life and overall well-being.

Prevention of Osteoporosis:

Estrogen plays a crucial role in maintaining bone density, and HRT can help reduce the risk of osteoporosis, a condition characterized by decreased bone mass and increased susceptibility to fractures. Estrogen supplementation can help slow down bone loss and promote bone health, particularly when started around the time of menopause.

Reduced Risk of Colon Cancer:

Long-term use of estrogen-only HRT has been associated with a reduced risk of colon cancer. The protective effect is believed to be related to estrogen's influence on the growth and development of colon cells.

Cardiovascular Benefits (Under Certain Conditions):

HRT, when initiated in the early stages of menopause for healthy women, may have cardiovascular benefits. Estrogen can have a positive impact on blood vessel function, lipid profiles, and plaque formation, potentially reducing the risk of heart disease in some women. However, it's important to note that the benefits and risks of cardiovascular outcomes with HRT may vary depending on individual factors and overall health status.

Management of Genitourinary Symptoms:

HRT, particularly vaginal estrogen therapy, can effectively address genitourinary symptoms such as vaginal dryness, itching, discomfort during intercourse, and urinary symptoms. Vaginal estrogen treatments help rejuvenate and restore moisture to the vaginal tissues, improving comfort and quality of life.

Con's of Using Hormone Replacement Therapy:

As with any medication, there are potential risks and side effects associated with HRT, such as:

Increased Risk of Breast Cancer

Long-term use of combined estrogen and progestin HRT has been associated with a slightly increased risk of breast cancer. The risk appears to be higher with longer durations of use. However, the risk decreases after stopping HRT, and the overall increase in absolute risk is still relatively small.

Increased Risk of Blood Clots

Both estrogen-only and combined HRT can increase the risk of developing blood clots, including deep vein thrombosis (DVT) and pulmonary embolism. This risk is higher in the first year of HRT use, particularly with oral forms of estrogen. Women with a history of blood clots or certain risk factors may have a higher risk.

Increased Risk of Stroke

The use of combined HRT, especially in older women, has been associated with a slightly increased risk of stroke. The risk is highest in the first few years of HRT use.

Increased Risk of Heart Disease

While estrogen can have cardiovascular benefits when initiated in the early stages of menopause for healthy women, the risks and benefits may vary depending on individual factors and overall health status. For certain women, particularly those who have existing cardiovascular conditions or multiple risk factors, the use of HRT may increase the risk of heart disease.

Increased Risk of Gallbladder Disease

Estrogen in HRT can increase the risk of gallbladder disease, including gallstones. Women with a history of gallbladder disease may have an increased risk when using HRT.

These risks should be carefully considered and discussed with a healthcare professional when making decisions about treatment options.

2. Non-Hormone Medications

Certain medications, such as selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs), which are commonly used as antidepressants, have been found to effectively reduce hot flashes and improve mood. Other medications, such as gabapentin and clonidine, may also be prescribed to manage specific menopause symptoms.

Anti Depressants for Treating Menopause:

Antidepressants are sometimes prescribed to help manage certain menopause symptoms, particularly mood changes and hot flushes. While these medications are primarily used to treat depression, they can be effective in addressing specific menopause-related symptoms. Here are some commonly used antidepressants for managing menopause symptoms:

Selective Serotonin Reuptake Inhibitors (SSRIs):

SSRIs, such as fluoxetine (Prozac), sertraline (Zoloft), and escitalopram (Lexapro), are commonly prescribed to treat depression and anxiety. They have also been found to help reduce the frequency and severity of hot flashes. SSRIs work by increasing the levels of serotonin, a neurotransmitter involved in regulating mood and body temperature.

Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs):

SNRIs, such as venlafaxine (Effexor) and desvenlafaxine (Pristiq), are another class of antidepressants used to treat depression and anxiety. They can be effective in reducing hot flashes and improving mood during menopause. SNRIs increase the levels of both serotonin and norepinephrine, which can help regulate body temperature and improve emotional well-being.

Tricyclic Antidepressants (TCAs):

TCAs, such as amitriptyline and nortriptyline, are older antidepressants that can also be used to manage menopause symptoms. They can help reduce hot flashes and improve mood, but they are generally prescribed less frequently due to their potential side effects and interactions with other medications.

3. Vaginal Estrogen (Low Hormone Therapy)

Vaginal estrogen therapy is a form of hormone replacement therapy (HRT) that specifically targets the symptoms of vaginal atrophy and dryness that can occur during menopause. It involves the use of estrogen delivered directly to the vaginal tissues in the form of creams, tablets, or vaginal rings.

Vaginal estrogen therapy is primarily used to address symptoms associated with vaginal atrophy, such as vaginal dryness, itching, burning, pain during intercourse (dyspareunia), and urinary symptoms (e.g., frequent urination, urinary urgency). These symptoms occur due to the decline in estrogen levels that happens during menopause. It delivers a low dose of estrogen directly to the vaginal tissues. This helps to rejuvenate and restore the health of the vaginal lining, increasing moisture and elasticity, and reducing symptoms of vaginal atrophy.

Vaginal estrogen therapy is available in different forms, including vaginal creams, vaginal tablets, and vaginal rings. Vaginal creams are applied directly into the vagina using an applicator. Vaginal tablets are inserted into the vagina using an applicator, and they dissolve slowly to release the estrogen. Vaginal rings are flexible rings that are inserted into the upper part of the vagina, where they continuously release a small amount of estrogen over time.

4. Gabapentin

Gabapentin is a medication that is commonly used to treat various conditions, including epilepsy/seizure disorders, neuropathic pain, and certain types of nerve-related pain. It works by affecting certain chemicals in the brain and nerves involved in the transmission of pain signals.

In addition to its approved uses, gabapentin has also been found to be effective in managing certain menopause symptoms, particularly hot flushes. It is believed that gabapentin can help regulate the release of neurotransmitters and reduce the excitability of nerves, which can contribute to the occurrence of hot flushes.

When used for menopause symptoms, gabapentin is typically prescribed off-label, which means it is being used for a purpose not specifically approved by regulatory authorities. The dose and duration of treatment may vary depending on individual needs and response.

Gabapentin: Common, long-term, and rare side effects

5. Clonidine

Clonidine is a medication that is primarily used to treat high blood pressure. However, it has also been found to be helpful in managing certain menopause symptoms, particularly hot flushes. Clonidine belongs to a class of medications known as alpha-2 adrenergic agonists, which work by stimulating certain receptors in the brain to help regulate blood pressure and reduce the activity of certain nerve pathways.

When used for menopause symptoms, clonidine is typically prescribed off-label, meaning it is being used for a purpose not specifically approved by regulatory authorities. It can be effective in reducing the frequency and severity of hot flushes by affecting the release of certain neurotransmitters and regulating the body's response to temperature changes.


There are various treatments available to manage the symptoms of menopause. The choice of treatment depends on the specific symptoms experienced and individual health considerations. Ask your Doctor which treatment is right for you.

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